|
KMID : 0624620170500040208
|
|
BMB Reports
2017 Volume.50 No. 4 p.208 ~ p.213
|
|
|
miR-374 promotes myocardial hypertrophy by negatively regulating vascular endothelial growth factor receptor-1 signaling
|
|
Lee Jong-Sub
Song Dong-Woo
Park Jei-Hyoung
Kim Jin-Ock
Cho Chung-Hee
Kim Do-Han
|
|
|
Abstract
|
|
|
|
Vascular endothelial growth factor (VEGF) is an essential cytokine that has functions in the formation of new blood vessels and regression of cardiac hypertrophy. VEGF/VEGF-receptor-1 (VEGFR1) signaling plays a key role in the regression of cardiac hypertrophy, whereas VEGF/VEGFR2 signaling leads to cardiac hypertrophy. In this study, we identified the prohypertrophic role of miR-374 using neonatal rat ventricular myocytes (NRVMs). Our results showed that overexpression of miR-374 activated G protein-coupled receptor-mediated pro-hypertrophic pathways by the inhibition of VEGFR1-dependent regression pathways. Luciferase assays revealed that miR-374 could directly target the 3′-untranslated regions of VEGFR1 and cGMP-dependent protein kinase-1. Collectively, these findings demonstrated that miR-374 was a novel pro-hypertrophic microRNA functioning to suppress the VEGFR1-mediated regression pathway.
|
|
|
KEYWORD
|
|
|
Cardiac hypertrophy, cGMP-dependent protein kinase-1, MicroRNA, Neonatal rat ventricular myocytes, Vascular endothelial growth factor signaling
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|